Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by inflammation and damage to various body tissues. It can affect any part of the body, but most commonly the skin, joints, kidneys, brain, and blood vessels. Symptoms vary widely, but can include fatigue, joint pain, fever, skin rashes, and anemia. Causes of SLE are not fully understood, but may be related to genetics or environmental triggers such as infections, drugs, and ultraviolet light. Diagnosis of SLE is made through a combination of physical examination, lab tests, and imaging studies. Treatment of SLE is aimed at controlling inflammation and minimizing damage to the body. Treatments may include medications such as corticosteroids and nonsteroidal anti-inflammatory drugs, lifestyle changes, and other therapies.